If that’s the case, third-party mouse management applications like SteerMouse can assign extra buttons to keystrokes and take the place of software that’s not Mac-compatible. If you’ve downloaded an app from an unknown source there is the potential for it to contain malware, which could also be the cause of the problem. Part 2. If the USB ports not working on your MacBook Pro or iMac is a recent issue and there doesn’t seem to be any problem with USB devices, it could be that an app is conflicting with USB functionality. Other times the mouse needs to be replaced. It does not have to say "Works with Mac". Magic Mouse 2, Magic Keyboard, Magic Keyboard with Numeric Keypad and Magic Trackpad 2 have built-in rechargeable batteries. Read this post, restarted, then let … Support will be highly appriciated IAm also facing the same issue,If any one know about it say the possible causes (Dont ask Mouse is connected and working in Windows) and the ways to fix the problem in MAC OSX. You may notice some difficulties in working with the mouse on the screen and sometimes you may find it … I have this problem with an Apple magic mouse (bluetooth) and a generic-ish USB keyboard connected to a 12/24 core "cheesegrater" mac pro under 10.12.6: Reboot after ten days or so, then there's no mouse pointer, no keyboard. All the normal buttons will work, the right and left and the middle Wheel button along with the wheel. Topher Kessler July 22, 2013 12:55 p.m. PT Left mouse click of usb and BT mice did not work with 2011 iMac. After reading the posts here I started looking for BT interference. Solution: Unplug the mac pro from the AC supply; Wait one minute for system controller to reset; Plug back in You can charge these devices by connecting them to a Mac or a USB power adapter using a Lightning to USB Cable. A Mouse is a Mouse. If the manufacturer’s configuration software doesn’t run on macOS, the Mac will detect the mouse as a pointing device, and extra buttons might not work properly. Most of the time these involve a USB mouse plugged into a bad USB port or a wireless mouse running out of batteries. If your mouse cursor disappears or freezes but the system is still responsive, then you can likely remedy the situation without hard-resetting your Mac. Took iMac to apple genius and their mouse worked perfectly. Tried restarting alone, but nothing. Left click stopped working entirely. Have brand new Mac pro with the touch bar. Top 7 Solutions to Mac Mouse Not Working: The mouse is probably the most essential device used to control your system, regardless of which OS you are using. If it has other side button or other special features then you might need the manufacturers software for those to function correctly. Using a Third-Party Mouse on Mac. 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